Slide 1:
Hed: Remedy of major hyperoxaluria
Dek: This uncommon dysfunction causes kidney stones and probably kidney injury. Study extra about your therapeutic choices.
Slide 2:
Main hyperoxaluria is a uncommon genetic dysfunction wherein your physique makes an excessive amount of of a substance known as oxalate.
When an excessive amount of oxalate builds up within the kidneys and combines with calcium, kidney stones kind and that, in flip, may cause kidney failure.
Slide 3:
There are three varieties of HP:
HP1
HP2
HP3
Therapeutic choices rely upon what kind of PH you have got, however the therapeutic purpose for all sorts of PH is to forestall oxalate from increase within the kidneys and different components of your physique.
Slide 4:
Some therapeutic and administration choices embrace:
Vitamin B6 (pyridoxine)
Excessive doses of vitamin B6 could also be useful in decreasing oxalate ranges. This remedy works for about 3 in 10 individuals. It’s only helpful for sufferers with HP1.
Slide 5:
Prescription medicines
Lumasiran and nedosiran might be given as injections beneath the pores and skin to cut back oxalate ranges. These medicines are solely helpful for sufferers with HP1.
Slide 6:
Drink loads of fluids
Ingesting loads of fluids (particularly water) day-after-day might be useful in flushing oxalate out of your physique.
Slide 7:
Citrate or bicarbonate salts
An excessive amount of acid in your urine will increase the danger of kidney stones. Devour citrate and bicarbonate salts similar to:
potassium citrate
Potassium bicarbonate
sodium citrate
baking soda
It might scale back the acidity of your urine.
Slide 8:
Keep away from excessive ranges of vitamin C
An excessive amount of vitamin C in your weight loss plan, from meals or dietary supplements, can enhance oxalate.
Slide 9:
Keep away from meals with a variety of oxalate
Meals with excessive ranges of oxalate embrace:
dried fruits
Chocolate
Candy potato
Plums
Beets
Rhubarb
Spinach
Tofu
Strawberries
In the event you resolve to eat these meals, additionally devour meals with a variety of calcium to forestall oxalate from reaching your kidneys and producing kidney stones.
Slide 10:
The effectiveness of therapies for major hyperoxaluria will rely in your normal well being and the way extreme your situation is.
Speak to your healthcare supplier to find out what may give you the results you want.
This academic useful resource was ready with the help of Alnylam.