Slide 1:
Hed: Treating Main Hyperoxaluria
Dek: This uncommon dysfunction causes kidney stones and presumably kidney injury. Discover out extra about your therapy choices.
Slide 2:
Main hyperoxaluria is a uncommon genetic dysfunction the place your physique creates an excessive amount of of a substance known as oxalate.
When an excessive amount of oxalate builds up within the kidneys and combines with calciumit types kidney stones and may result in kidney failure.
Slide 3:
There are three kinds of PH:
PH1
PH2
PH3
Remedy choices depend upon which sort of PH you might have, however the therapy purpose for all types of PH is to stop oxalate from build up within the kidneys and different elements of your physique.
Slide 4:
Some therapy choices embody:
Vitamin B6 (pyridoxine)
When taken at excessive doses, vitamin B6 can assist decrease oxalate ranges. This therapy works for about 3 out of 10 individuals. It is just helpful for sufferers with PH1.
Slide 5:
Prescription Medicines
Lumasiran and nedosiran may be given as injections underneath the pores and skin to decrease oxalate ranges. These drugs are solely helpful for sufferers with PH1.
Slide 6:
Ingesting Loads of Fluids
Ingesting numerous fluid (particularly water) every day can assist flush the oxalate out of your physique.
Slide 7:
Citrate or Bicarbonate Salts
An excessive amount of acid in your urine will increase the danger of kidney stones. Consuming citrate and bicarbonate salt like:
Potassium citrate
Potassium bicarbonate
Sodium citrate
Sodium bicarbonate
can decrease the acidity of your urine.
Slide 8:
Avoiding Excessive Ranges of Vitamin C
An excessive amount of vitamin C in your food plan — from meals or dietary supplements — can increase oxalate.
Slide 9:
Avoiding Meals Excessive in Oxalate
Excessive-oxalate meals embody:
Nuts
Chocolate
Candy potatoes
Plums
Beets
Rhubarb
Spinach
Tofu
Strawberries
For those who select to eat these meals, eat calcium-rich meals as effectively to assist stop the oxalate from reaching your kidneys and creating kidney stones.
Slide 10:
How effectively major hyperoxaluria remedies work depends upon your total well being and the way extreme your situation is.
Speak to your healthcare supplier about what may be just right for you.
This academic useful resource was created with help from Alnylam.